Principal Software Engineer

Location

This is a hybrid remote/in-office role.

*Medidata follows a hybrid office policy in which employees who are hired for an in-person position are expected to work on site a certain number of days per week following Company policy.*

About our Company

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Medidata is powering smarter treatments and healthier people through digital solutions to support clinical trials. Celebrating over 25 years of ground-breaking technological innovation across more than 38,000 trials and 12 million patients, Medidata offers industry-leading expertise, analytics-powered insights, and one of the largest clinical trial data sets in the industry. More than 1 million registered users across approximately 2,300 customers trust Medidata's seamless, end-to-end platform to improve patient experiences, accelerate clinical breakthroughs, and bring therapies to market faster. A Dassault Systèmes brand (Euronext Paris: FR0014003TT8, DSY.PA), Medidata is headquartered in New York City and has been recognized as a Leader by Everest Group and IDC. Discover more at www.medidata.com. Listen to our latest podcast, from Dreamers to Disruptors, and follow us at @Medidata.

The Role

You will define the technical direction for Medidata's Platform engineering organization — the systems, infrastructure, and practices that power clinical trial operations for the world's largest pharmaceutical companies. You set architectural direction across multiple teams and time horizons, translate business strategy into durable technical capabilities, and develop the Staff and Senior Staff engineers who execute within that direction.

The platform is in the middle of a fundamental shift. AI and agentic systems are moving from experimental features to core infrastructure. You will be the architectural authority for how this transformation plays out — not within a single team, but across every team that builds on the platform. You will determine where AI agents operate in production